be in charge of 是主动的,指对...有掌控权，负责某事的意思。
be in the charge of 是被动的,指被...控制/支配/管理。
be in charge of
负责；掌理
双语例句
1.
To ensure consistency (and finality) in decisions and direction, as well as rapid and clear decision-making, one person must ultimately be in charge of the day-to-day effort.
这个人 在决策和指导中确保连续性（和结果）以及快速清晰的决策制定。 这个人必须最终负责每天的日常工作。
2.
The document also said that the MoC would be in charge of punishing companies that operate online games without GAPP approval.
同时表示将由文化部负责惩罚那些在得到新闻出版总署批准前即运营网络游戏的公司。
be in the charge of
在某人的掌管下
处于某人的负责之下
双语例句
1.
Waters and sluices along rivers shall be in the charge of the using or administering units of the bank lines and sluices;
河道的沿岸水域、水闸，由岸线、水闸的使用或者管理单位负责；
2.
Product design and development activities are to be in the charge of people who are qualified for realizing design requirements.
产品设计和开发活动应由具备实现设计要求资格的人员担任。
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