Over one million Americans are living with the virus, out of an estimated thirty-three million people worldwide.
这句话也可以倒过来说...
Out of an estimated thirty-three million people worldwide, over one million americans are living with the virus.
在全球大约3300万人当中,有一百万的美国人已经感染病毒。(为强调后半句而倒过来,意思是一样的。)
Out of 在这里的意思,可以理解为:在...当中
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